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Depression Overview ›› Depression Overview
People who have been diagnosed and or treated for depression prior to quitting smoking should monitor any changes in symptoms carefully as they begin and move forward in their smoke-free journey. Some may experience changes in their symptoms, which may necessitate a change in treatment. If you experience drastic mood changes when you quit smoking, or if they persist for an extended period of time, a visit with your physician is advisable.

If you have depression, smoking or exposure to secondhand smoke could make your symptoms worse. Likewise, if you’re a smoker, an increased risk of depression is one more reason you should try to stop smoking and avoid secondhand smoke exposure.
Remember that it is completely natural to feel irritable and sad in the first days and weeks after you stop smoking. Also keep in mind that many smokers who have depression experience more severe nicotine withdrawal symptoms than those who don’t. But sticking with your plan and staying away from cigarettes is worth it — it will help you feel better in the long run and, ultimately, proud that you have conquered the challenging task of quitting smoking.
Sources and Additional Information:
http://www.everydayhealth.com/depression/smoking-and-depression.aspx